OAKLAND -- The family of Dr. Zehra Attari has offered a $10,000 reward for any information leading to the missing South Bay pediatrician's safe return to her loved ones.

Oakland and San Jose police along with family and friends continued desperate search Wednesday for the doctor, who failed to appear at a meeting and has now been missing since Monday night.

San Jose police Det. Steve Brownlee said the apparent disappearance of Attari, 55, is "extremely troubling" because "she's extremely solid and wouldn't just up and take off."

Brownlee said Attari, a pediatrician who lives in San Jose and works in Oakland, left her office at 27th Avenue and International Boulevard around 5 p.m. Monday to drive to a medical conference on South Loop Road in Alameda.

But she never made it to the conference and her husband called San Jose police Monday night to report her missing, Brownlee said.

He said authorities were concerned because it was raining Monday night and Attari wasn't familiar with the location of the meeting.

"She may have gotten off course," Brownlee said.

He said Attari does a lot of work with the poor and said her office "is not in the best neighborhood."

Attari was driving a 2000 gray Honda Accord with the license plate 4MUH810, Brownlee said.

On Wednesday, friends, family and members of her mosque in San Jose hit the streets around her Oakland clinic with missing person flyers in hand. The case has been transferred from San Jose, where Attari lives, to Oakland, where she disappeared.

The family is also asking Oakland police to look into any past cases of child abuse that Dr. Attari reported to police in case there has been foul play and her disappearance is some type of retaliation.

Oakland police, meanwhile, retraced the route Attari may have taken Monday night to see if they can find anyone who saw her, Brownlee said.

He said anyone who has information about Attari should call him at (408) 277-4786.

Annie Dandavati, a friend of Attari who lives in San Jose, said, "This whole thing doesn't make any sense."

She said, "Somebody has to have seen something."

Dandavati said Attari is part of "a very united, solid family" and people and community members are concerned about her disappearance.

She said she's doing all she can to get as many people as possible involved in the search for Attari and has contacted the office of Oakland Mayor Jerry Brown, local police and other agencies.