A Novato man suffered major and potentially life-threatening injuries in a two-car crash on southbound U.S. Highway 101 south of the Redwood Sanitary Landfill and Recycling Center overpass Tuesday afternoon, a California Highway Patrol Officer said.

Roddy Morales-Andino, 26, was taken by medical helicopter to Santa Rosa Memorial Hospital after the 1:10 p.m. crash that closed all lanes of the highway for approximately 36 minutes while the helicopter was on the ground, CHP Officer Andrew Barclay said.

Witnesses said Andino was speeding and making aggressive lane changes in his 2010 Volkswagen GTI before he lost control and crashed into the back of a GMC Yukon driven by Sylvie Demoreira, 36, of Novato.

Demoreira drove the Yukon to the right shoulder of the highway and Andino's Volkswagen stopped sideways between both lanes of traffic, Barclay said.

Demoreira suffered minor injuries and was taken to Novato Community Hospital, Barclay said.

Andino's injuries were major and potentially life-threatening, Barclay said.

The collision was still under investigation Tuesday evening, Barclay said.