San Francisco, CA -- (Sports Network) - San Francisco 49ers running back Frank Gore is questionable for Monday's contest against Seattle after limited participation in practice on Friday, while recovering from a sprained ankle.

Gore suffered the injury on October 21 during the 49ers' 33-15 loss against the New York Giants.

The former Miami Hurricane has rushed for 435 yards on 110 carries this season.

Seahawks running back Shaun Alexander remains questionable after not participating in practice on Friday. Alexander suffered a knee injury during Sunday's 33-30 overtime loss to Cleveland.

The eight-year pro, has amassed 492 yards on the ground with two touchdowns this season.