The ad features Newsom with redwood trees in the background, comparing Californians to the "mighty redwood forests."
"As your Governor, whatever challenges come our way, I will always lead with the California way," said Newsom. "With compassion, common-sense, telling the truth, following science, treasuring diversity, defending democracy, protecting our planet and always planting seeds for the future."
Officials said this is the first in what will be a multi-million-dollar digital and TV campaign.
The 2022 California gubernatorial election will take place on November 8, 2022, to elect the governor, with the statewide top-two primary election taking place on June 7, 2022.