The defending NFC champions are 0-1 — and will try to avoid a two-game skid to start the year when they face the hapless New York Jets at MetLife Stadium on Sunday.
Richard Sherman will be on the injured reserve list.
NFL Network first reported the injury.
NFL Network reported that it was an old calf strain that flared up again, but Sherman is expected to quickly return.
The San Francisco 49ers on Tuesday made two rent payments for Levi's Stadium to the Santa Clara Stadium Authority, a payment for September that was past due and the subject of a dispute, and a second for October.
DeAndre Hopkins had a career-high 14 catches for 151 yards in his Arizona debut and set up Kenyan Drake’s 1-yard TD run with 5:03 to play that led the Cardinals over the San Francisco 49ers 24-20 on Sunday.
The game risked being canceled if the air quality surpassed the 200 AQI threshold.
With their season opener days away, the 49ers reflected on the impact of the wildfires in California and the smoke hovering above their stadium in Santa Clara.
Get ready to see the phrase on your 49ers swag.
Samuel broke his foot in June during informal workouts with teammates in Tennessee and hasn’t been able to practice since.
The move with Samuel means he is eligible to play the season opener Sept. 13 against Arizona instead of staying on the NFI list because of a broken foot for at least the first eight weeks of the season.
This comes after a broken foot in mid-June.
The 49ers are scheduled to play road games Sept. 20 against the New York Jets and Sept. 27 against the New York Giants at the New Jersey Meadowlands.
The list is used for players who either test positive for the coronavirus or have been in close contact with an infected person.
Any slip up could be costly in one of NFL’s toughest divisions.
The team left the door open for fans to return later in the season.
Goodell said the players' peaceful protests were never about the American flag.
The San Francisco 49ers have reached a deal with star tight end George Kittle for five more years with the team.
Former NFL quarterback Colin Kaepernick and Dr. Anthony Fauci have been recognized by the Robert F. Kennedy Human Rights Organization to receive its most prestigious award. They were two of the five people chosen for the 2020 RFK Ripple of Hope Award.
A person familiar with the deal says the sides agreed on Wednesday to replace the original six-year contract Lynch signed in 2017.