Highway 84 near Little Valley Road, located between Sunol and Livermore, is closed in both directions due to a traffic collision.
Two vehicles collided, which resulted in one of them catching fire.
Officials have not released an estimation on when the road will reopen.
KTVU's SkyFox flew over the scene, showing traffic backed up in both directions for miles.
KTVU will update this story as more information is made available.