According to CPS, Spacey was also charged with causing a person to engage in penetrative sexual activity without consent.
The charges come after a review of evidence gathered during an investigation by the Metropolitan Police.
The alleged incidents took place in London between March 2005 and August 2008, and in western England in April 2013.
Spacey, a 62-year-old double Academy Award winner, was questioned by British police in 2019 about claims by several men that he had assaulted them.
The former "House of Cards" star ran London’s Old Vic Theatre between 2004 and 2015.
Spacey won a best supporting actor Academy Award for the 1995 film "The Usual Suspects" and a lead actor Oscar for the 1999 movie "American Beauty."
His celebrated career came to an abrupt halt in 2017 when actor Anthony Rapp accused the star of assaulting him at a party in the 1980s, when Rapp was a teenager.
Spacey denies the allegations and is currently trying to have a sex abuse lawsuit from Rapp in New York thrown out.
A criminal case brought against him, an indecent assault and battery charge stemming from the alleged groping of an 18-year-old man at a Nantucket resort, was dismissed by Massachusetts prosecutors in 2019.
The Associated Press contributed to this report.